Sweritranslactone D, a hepatoprotective novel secoiridoid dimer with tetracyclic lactone skeleton from heat-transformed swertiamarin
| Autor: | Fang-Yan He, Ping-Xing Qi, Sheng-Nan Du, Tan Wenhong, Ma Xiaoxia, Afsar Khan, Ya-Dan Zou, Zhou Zhihong, Lu Liu, Yang Zhuya |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Hot Temperature
Stereochemistry Dimer Iridoid Glucosides Decoction Protective Agents 01 natural sciences Swertia mileensis Cell Line Lactones Mice chemistry.chemical_compound Drug Discovery Active component Animals Humans Chinese pharmacopoeia Swertia Pharmacology chemistry.chemical_classification Molecular Structure 010405 organic chemistry General Medicine Skeleton (computer programming) 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Pyrones Chemical and Drug Induced Liver Injury Lactone Drugs Chinese Herbal |
| Zdroj: | Fitoterapia. 151:104879 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2021.104879 |
| Popis: | Swertia mileensis, known as Qing-Ye-Dan (QYD), has been documented in Chinese Pharmacopoeia to cure hepatitis. Interestingly, its announced main active component, swertiamarin, could not be detected in the decoction, which indicated that the efficacy of QYD might be attributed to heat-transformed products of swertiamarin (HTPS). Further investigation on HTPS led to the isolation of sweritranslactone D (1), a novel secoiridoid dimer possessing a tetracyclic lactone skeleton, with better hepatoprotective activity than N-acetyl-L-cysteine in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect