Dys-regulation of peripheral transcript levels of ecto-5’-nucleotidase in multiple sclerosis patients

Autor:	Mohammad Taheri, Soudeh Ghafouri-Fard, Farzad Kobarfard, Rezvan Noroozi, Amirreza Dowlati Beirami
Rok vydání:	2019
Předmět:	Adult Genetic Markers Male medicine.medical_specialty Multiple Sclerosis Adolescent Immunology Gene Expression Disease GPI-Linked Proteins 5'-nucleotidase Pathogenesis Young Adult 03 medical and health sciences NT5E 0302 clinical medicine Immune system Nucleotidase Internal medicine Humans Immunology and Allergy Medicine 5'-Nucleotidase business.industry Multiple sclerosis Bayes Theorem General Medicine Middle Aged medicine.disease Adenosine Endocrinology 030220 oncology & carcinogenesis Female business 030215 immunology medicine.drug
Zdroj:	Human Antibodies. 27:161-165
ISSN:	1875-869X 1093-2607
Popis:	CD73, also entitled as ecto-5'-nucleotidase (NT5E), is an ecto-nucleotidase that contributes in the breakage of extracellular ATP to adenosine and the preservation of immune balance. In spite of acknowledged role for immune response imbalance in the pathogenesis of multiple sclerosis (MS), data regarding NT5E expression in MS patients are scarce. In the current study, we assessed expression of NT5E in peripheral blood of MS patients and healthy subjects to unravel its role in the pathogenesis of MS. Results of Multilevel Bayesian model showed no significant difference in NT5E expression between total MS patients and healthy subjects. However, its expression was significantly lower in male MS patients compared with male controls (P= 0.031, 95% credible intervals: [-6.93, -0.56]). No significant correlation was found between expression of NT5E and age in any study subgroups. Remarkably, NT5E transcript levels had 92.31% sensitivity and 80% specificity in diagnosis of MS disease. The diagnostic power of NT5E transcripts was 86.2% based on AUC values. Consequently, the current study indicates the role of NT5E in the pathogenesis of MS disease in male subjects. Moreover, expression level of this gene might be used as a putative marker especially in male MS patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c218ff91d3f9a9f3c37cc7781842b0 https://doi.org/10.3233/hab-190362 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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