Association between periodontitis and mortality in stages 3–5 chronic kidney disease: NHANES III and linked mortality study
| Autor: | Thomas Dietrich, Iain L. C. Chapple, Praveen Sharma, Paul Cockwell, Charles J. Ferro |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology National Health and Nutrition Examination Survey urologic and male genital diseases survival 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine medicine Humans NHANES 030212 general & internal medicine Renal Insufficiency Chronic Periodontitis Periodontal Diseases Survival analysis Aged Epidemiology (Cohort study or case‐control study) business.industry Mortality rate Confounding 030206 dentistry Middle Aged Nutrition Surveys medicine.disease female genital diseases and pregnancy complications Cardiovascular Diseases Cohort Periodontics Female business chronic kidney disease Kidney disease |
| Zdroj: | Journal of Clinical Periodontology |
| ISSN: | 1600-051X 0303-6979 |
| DOI: | 10.1111/jcpe.12502 |
| Popis: | Introduction Periodontitis may add to the systemic inflammatory burden in individuals with chronic kidney disease (CKD), thereby contributing to an increased mortality rate. This study aimed to determine the association between periodontitis and mortality rate (all-cause and cardiovascular disease-related) in individuals with stage 3–5 CKD, hitherto referred to as “CKD”. Methods Survival analysis was carried out using the Third National Health and Nutrition Examination Survey (NHANES III) and linked mortality data. Cox proportional hazards regression was employed to assess the association between periodontitis and mortality, in individuals with CKD. This association was compared with the association between mortality and traditional risk factors in CKD mortality (diabetes, hypertension and smoking). Results Of the 13,784 participants eligible for analysis in NHANES III, 861 (6%) had CKD. The median follow-up for this cohort was 14.3 years. Adjusting for confounders, the 10-year all-cause mortality rate for individuals with CKD increased from 32% (95% CI: 29–35%) to 41% (36–47%) with the addition of periodontitis. For diabetes, the 10-year all-cause mortality rate increased to 43% (38–49%). Conclusion There is a strong, association between periodontitis and increased mortality in individuals with CKD. Sources of chronic systemic inflammation (including periodontitis) may be important contributors to mortality in patients with CKD. |
| Databáze: | OpenAIRE |
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