Prognostic value of human papillomavirus detection and the eighth edition of the TNM classification staging system in oropharyngeal squamous cell carcinoma: A single-center Polish study
| Autor: | Monika Durzynska, Dorota Kiprian, Anna Szumera-Cieckiewicz, Pawel Leszczynski, Aleksandra Florek, Miroslaw Snietura, Irmina Maria Michalek, Elwira Bakula-Zalewska, Monika Prochorec-Sobieszek |
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| Rok vydání: | 2022 |
| Předmět: |
Squamous Cell Carcinoma of Head and Neck
Papillomavirus Infections Alphapapillomavirus Prognosis Pathology and Forensic Medicine Oropharyngeal Neoplasms Head and Neck Neoplasms Carcinoma Squamous Cell Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Surgery Poland Oral Surgery Papillomaviridae Neoplasm Staging Retrospective Studies |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 133:698-705 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2021.12.126 |
| Popis: | This study aimed to determine human papillomavirus (HPV) status and genotypes, the HPV status-dependent survival, and the applicability of the eighth TNM classification in Polish patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC).All patients with primary OPSCC, diagnosed and treated from 2007 to 2017 at the National Research Institute of Oncology, Warsaw, Poland, who underwent radical radiotherapy were included. The Kaplan-Meier method was deployed to produce 3- and 5-year observed survival (OS) estimates.A total of 110 OPSCC cases were identified. Double positivity for HPV (IHC p16The majority of Polish patients with OPSCC are HPV16-positive. In HPV-related OPSCC, survival rates are significantly higher than in HPV-negative OPSCC. The findings support the requirement of HPV testing in Polish patients with OPSCC because HPV-positive status influences tumor prognosis. |
| Databáze: | OpenAIRE |
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