A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses
| Autor: | Neetu Singh, Aseem Pandey, Lakshmi Jayashankar, Mary Hoelscher, Sanjay Garg, Suryaprakash Sambhara, Vic Veguilla, Suresh K. Mittal, Ruben O. Donis, Yumi Matsuoka, Jacqueline M. Katz |
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| Rok vydání: | 2008 |
| Předmět: |
Orthomyxoviridae
Biology medicine.disease_cause Antibodies Viral Article Microbiology Viral vector Adenoviridae Mice Neutralization Tests Pandemic Influenza Human medicine Immunology and Allergy Animals Humans Clade Lung Mice Inbred BALB C Vaccines Synthetic Influenza A Virus H5N1 Subtype Vaccination biology.organism_classification Virology Influenza A virus subtype H5N1 Nucleoprotein Infectious Diseases Hemagglutinins Nucleoproteins Influenza Vaccines Viral disease |
| Zdroj: | The Journal of infectious diseases. 197(8) |
| ISSN: | 0022-1899 |
| Popis: | Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses. |
| Databáze: | OpenAIRE |
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