Metabolic syndrome and risk of subsequent colorectal cancer
| Autor: | Alina Cristina Silaghi, M L Rusu, Raluca Pais, Horatiu Silaghi, Dan L. Dumitrascu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer Review Insulin resistance Risk Factors Diabetes mellitus Internal medicine medicine Hyperinsulinemia Humans Abdominal obesity Metabolic Syndrome business.industry Gastroenterology Cancer General Medicine medicine.disease Obesity Endocrinology Obesity Abdominal Metabolic syndrome medicine.symptom Insulin Resistance business Colorectal Neoplasms |
| Popis: | The metabolic syndrome and visceral obesity have an increasing prevalence and incidence in the general population. The actual prevalence of the metabolic syndrome is 24% in US population and between 24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES III, INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944,717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical significance and may have profound health benefits on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies. |
| Databáze: | OpenAIRE |
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