Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians
| Autor: | Dejan Trajkov, Snezhana Mishevska-Perchinkova, Mirko Spiroski, Anzelika Karadzova-Stojanoska, Ana Strezova, Aleksandar Petlichkovski |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_treatment
Population Arthritis Polymorphism Single Nucleotide Arthritis Rheumatoid Rheumatology Genotype Ethnicity Humans Medicine Genetic Predisposition to Disease Allele education Gene Genotyping Genetics education.field_of_study Tumor Necrosis Factor-alpha business.industry Interleukins Haplotype General Medicine medicine.disease Republic of North Macedonia Cytokine Haplotypes Immunology business |
| Zdroj: | Clinical Rheumatology. 28:1291-1300 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s10067-009-1238-4 |
| Popis: | To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against RA in Macedonians. In this study, 301 healthy unrelated individuals and 85 patients with RA were studied. Cytokine genotyping was performed by PCR with sequence-specific priming (PCR-SSP) (Heidelberg kit). Results showed susceptible association for four cytokine alleles, six cytokine genotypes, one haplotype, and four combinations of haplotypes, while protective associations were found for four cytokine alleles, three cytokine genotypes, three haplotypes, and only one combination of haplotypes. These results suggest that IL-4 -1098, IL-4 -590, IL-10 -1082, IL-10 -819, IL-2 -330, IL-6 -174, and TNF-alpha -238 cytokine gene polymorphisms might be significantly associated and affect host susceptibility and/or resistance to RA in Macedonians. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink