The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study
| Autor: | Stefan Krömer, Niels Rahe-Meyer, Anika Frese-Gaul, Nilufar Foadi, Matthias Karst, Christian Weilbach |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
long-term outcome
medicine.medical_specialty medicine.medical_treatment Knee replacement Physical function Medium term Intrathecal morphine recovery 03 medical and health sciences 0302 clinical medicine Quality of life perioperative analgesia 030202 anesthesiology medicine intrathecal opioid Journal of Pain Research Original Research Bupivacaine business.industry Surgery Anesthesiology and Pain Medicine Anesthesia Orthopedic surgery adjunct Morphine business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Pain Research |
| ISSN: | 1178-7090 |
| Popis: | Nilufar Foadi,1,* Matthias Karst,1,* Anika Frese-Gaul,2 Niels Rahe-Meyer,3 Stefan Krömer,1 Christian Weilbach4 1Department of Anesthesiology and Intensive Care Medicine, Pain Clinic, Hannover Medical School, Hannover, 2Department of Psychosomatic Medicine, AHG Psychosomatische Klinik Bad Pyrmont, Bad Pyrmont, 3Department of Anesthesiology and Operative Intensive Care Medicine, Franziskus Hospital, Bielefeld, 4Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Medicine, St.JosefsâHospital Cloppenburg, Cloppenburg, Germany *These authors contributed equally to this work Objective: In orthopedic surgery, it is well known that the use of intrathecal morphine (ITM) leads to an improved quality of postoperative analgesia. Little is known how this improved analgesia affects the long-term course after surgery.Study design: A randomized, double-blind trial.Setting: Academic medical center.Subjects: Forty-nine patients undergoing total hip or knee replacement surgery in spinal anesthesia.Methods: Patients were randomly assigned to receive either 0.1 mg (n=16) or 0.2 mg (n=16) morphine sulfate intrathecally or physiological saline (n=17) added to 3 mL 0.5% isobaric bupivacaine for spinal anesthesia. As a function of the quality of the short-term postoperative analgesia, the effect on recovery and quality of life was evaluated at various time points up to 26 weeks after surgery.Results: In both ITM groups, the additionally required postoperative systemic morphine dose was significantly reduced compared with the placebo group (P=0.004). One week after operation, patients with ITM reported significantly less pain at rest (P=0.01) compared to the placebo group. At discharge, in comparison with the 0.1 mg ITM and placebo group, the 0.2mg ITM group showed a higher degree of impairment regarding pain, stiffness, and physical function of the respective joint (P=0.02). Over the further follow-up period of 6 months after surgery, recovery and the quality of life did not differ significantly between the three study groups (P>0.2).Conclusion: Morphine (0.1 mg) as adjunct to 0.5% bupivacaine for spinal anesthesia is effective to produce a pronounced postoperative analgesia with a beneficial analgesic effect up to 1 week after surgery. With this study design, the different quality of postoperative analgesia had no effect on quality of life and recovery in patients over the 6-month follow-up period. In the medium term, ITM may induce hyperalgesic effects. Keywords: intrathecal opioid, adjunct, perioperative analgesia, long-term outcome, recovery |
| Databáze: | OpenAIRE |
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