Effect of the catechol‐ O ‐methyltransferase Val 158 Met polymorphism on theory of mind in obesity
| Autor: | María Ángeles Jurado, C. Sánchez-Garre, Xavier Caldú, Jonatan Ottino-Gonzalez, Encarnació Tor, María‐José Sender‐Palacios, Imma Hernan, Maite Garolera, Jean-Claude Dreher |
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| Přispěvatelé: | Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
050103 clinical psychology
Catechol-O-methyl transferase media_common.quotation_subject [SCCO.NEUR]Cognitive science/Neuroscience 05 social sciences Wechsler Adult Intelligence Scale medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health Clinical Psychology Eating disorders 0302 clinical medicine Feeling Wisconsin Card Sorting Test Social cognition Theory of mind medicine 0501 psychology and cognitive sciences Psychology Psychosocial media_common Clinical psychology |
| Zdroj: | European Eating Disorders Review European Eating Disorders Review, Wiley, 2019, 27 (4), pp.401-409. ⟨10.1002/erv.2665⟩ |
| ISSN: | 1072-4133 |
| DOI: | 10.1002/erv.2665⟩ |
| Popis: | Obesity is often accompanied with psychosocial adjustment problems, such as difficulties in social interactions and social withdrawal. A key aspect of social cognition is theory of mind, which allows inferring mental states, feelings, motivations, and beliefs of others and to use this information to predict their future behaviour. Theory of mind is highly dependent on prefrontal dopaminergic neurotransmission, which is regulated by catechol-O-methyltransferase (COMT) activity. We aimed at determining whether theory of mind is altered in obesity and if this ability is modulated by COMT. Fifty patients with obesity and 47 normal-weight individuals underwent the Reading the Mind in the Eyes Test, the Wisconsin Card Sorting Test, and the Vocabulary subscale of the Wechsler Adult Intelligence Scale. The genotype for the COMT Val 158 Met functional polymorphism was determined for all subjects. Patients with obesity obtained significantly lower scores in the negative items of the Reading the Mind in the Eyes Test than normal-weight subjects. Further, an interaction effect was observed between group and COMT genotype. Specifically, the presence of the Met allele was associated to a better identification of negative mental states only in patients with obesity. Our results indicate that obesity is accompanied with difficulties in theory of mind and that this ability is influenced by the COMT genotype. |
| Databáze: | OpenAIRE |
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