The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia
| Autor: | Matthew H. Perkins, Klaudiusz R. Weiss, Michael A. Barry, Colin G. Evans, Jian Jing, Elizabeth C. Cropper |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Interneuron Cognitive Neuroscience Repetition priming Neuroscience (miscellaneous) Stimulation Neurosciences. Biological psychiatry. Neuropsychiatry 03 medical and health sciences Eating Cellular and Molecular Neuroscience 0302 clinical medicine mollusc Interneurons Aplysia medicine Animals Neurons biology Central pattern generator Feeding Behavior Brief Research Report biology.organism_classification central pattern generators Sensory Systems Ganglia Invertebrate command neuron 030104 developmental biology medicine.anatomical_structure Command neuron Neuron Neuroscience Priming (psychology) human activities 030217 neurology & neurosurgery feeding RC321-571 |
| Zdroj: | Frontiers in Neural Circuits, Vol 15 (2021) Frontiers in Neural Circuits |
| ISSN: | 1662-5110 |
| DOI: | 10.3389/fncir.2021.685222 |
| Popis: | Multiple projection neurons are often activated to initiate behavior. A question that then arises is, what is the unique functional role of each neuron activated? We address this issue in the feeding system of Aplysia. Previous experiments identified a projection neuron [cerebral buccal interneuron 2 (CBI-2)] that can trigger ingestive motor programs but only after it is repeatedly stimulated, i.e., initial programs are poorly defined. As CBI-2 stimulation continues, programs become progressively more ingestive (repetition priming occurs). This priming results, at least in part, from persistent actions of peptide cotransmitters released from CBI-2. We now show that in some preparations repetition priming does not occur. There is no clear seasonal effect; priming and non-priming preparations are encountered throughout the year. CBI-2 is electrically coupled to a second projection neuron, cerebral buccal interneuron 3 (CBI-3). In preparations in which priming does not occur, we show that ingestive activity is generated when CBI-2 and CBI-3 are coactivated. Programs are immediately ingestive, i.e., priming is not necessary, and a persistent state is not induced. Our data suggest that dynamic changes in the configuration of activity can vary and be determined by the complement of projection neurons that trigger activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|