Cyclodextrins: A promising drug delivery vehicle for bisphosphonate
| Autor: | Maelle Monteil, Steven Ruellan, Marc Lecouvey, David Landy, Isabelle Mallard |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrins Drug Carriers Diphosphonates Polymers and Plastics Cyclodextrin 010405 organic chemistry Organic Chemistry technology industry and agriculture Isothermal titration calorimetry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Bioavailability Solubility chemistry Stability constants of complexes Drug delivery Materials Chemistry Side chain Molecule Organic chemistry Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Carbohydrate Polymers. 156:285-293 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2016.09.030 |
| Popis: | Bisphosphonates are well established pharmaceutical drugs with wide applications in medicine. Nevertheless, the side chain and the nature of phosphorous groups could induce a poor aqueous solubility and act on their bioavailability. At the same time, cyclodextrins are cage molecules that facilitate transport of hydrophobic molecules to enhance the intestinal drug absorption of these molecules by forming inclusion complexes. Here we demonstrate that cyclodextrins could be used as a bisphosphonate carrier. The formation of cyclodextrins-bisphosphonate complexes was characterized by 1D and 2D NMR spectroscopy, Isothermal Titration Calorimetry and UV-vis spectroscopy. The results revealed that only the side chain of bisphosphonate was involved in the inclusion phenomenon and its length was a crucial parameter in the control of affinity. Findings from this study suggest that cyclodextrin will be a useful carrier for bisphosphonates. |
| Databáze: | OpenAIRE |
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