Voluntary Wheel Running Exercise Evoked by Food-Restriction Stress Exacerbates Weight Loss of Adolescent Female Rats But Also Promotes Resilience by Enhancing GABAergic Inhibition of Pyramidal Neurons in the Dorsal Hippocampus
| Autor: | Chiye Aoki, Yi Wen Chen, Kei Tateyama, Alex D. Reyes, Jia Yi Wang, Irene Yu, Tara G. Chowdhury, Gauri S. Wable |
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| Rok vydání: | 2018 |
| Předmět: |
Cognitive Neuroscience
Physical Exertion Glutamate decarboxylase Hippocampus Motor Activity Hippocampal formation Biology 050105 experimental psychology Rats Sprague-Dawley Synapse 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Weight loss Adaptation Psychological Weight Loss medicine Animals 0501 psychology and cognitive sciences Receptor gamma-Aminobutyric Acid GABAA receptor Pyramidal Cells 05 social sciences Neural Inhibition Original Articles Inhibitory Postsynaptic Potentials GABAergic Female medicine.symptom Food Deprivation Neuroscience Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Cereb Cortex |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhy283 |
| Popis: | Adolescence is marked by increased vulnerability to mental disorders and maladaptive behaviors, including anorexia nervosa. Food-restriction (FR) stress evokes foraging, which translates to increased wheel running exercise (EX) for caged rodents, a maladaptive behavior, since it does not improve food access and exacerbates weight loss. While almost all adolescent rodents increase EX following FR, some then become resilient by suppressing EX by the second–fourth FR day, which minimizes weight loss. We asked whether GABAergic plasticity in the hippocampus may underlie this gain in resilience. In vitro slice physiology revealed doubling of pyramidal neurons’ GABA response in the dorsal hippocampus of food-restricted animals with wheel access (FR + EX for 4 days), but without increase of mIPSC amplitudes. mIPSC frequency increased by 46%, but electron microscopy revealed no increase in axosomatic GABAergic synapse number onto pyramidal cells and only a modest increase (26%) of GABAergic synapse lengths. These changes suggest increase of vesicular release probability and extrasynaptic GABAA receptors and unsilencing of GABAergic synapses. GABAergic synapse lengths correlated with individual’s suppression of wheel running and weight loss. These analyses indicate that EX can have dual roles—exacerbate weight loss but also promote resilience to some by dampening hippocampal excitability. |
| Databáze: | OpenAIRE |
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