Promoting ossification of calvarial defects in craniosynostosis surgery by demineralized bone plate and bone dust in different age groups

Autor: M. Savolainen, Antti Ritvanen, Junnu Leikola, Pia Vuola, Jyri Hukki, J. Telkkä
Přispěvatelé: Plastiikkakirurgian yksikkö, Clinicum, Department of Surgery, HUS Musculoskeletal and Plastic Surgery
Rok vydání: 2016
Předmět:
Male
Dentistry
Bone Matrix
HARVEST
Craniosynostosis surgery
ANGIOGENESIS
0302 clinical medicine
Osteogenesis
10. No inequality
Child
OUTCOMES
Bone Demineralization Technique
Demineralized bone matrix
Calvarial
INTRACRANIAL VOLUME
dBm
Calvarial reconstruction
3. Good health
Plastic surgery
030220 oncology & carcinogenesis
Child
Preschool
Demineralized bone
Female
medicine.symptom
Bone Plates
medicine.medical_specialty
reconstruction
Adolescent
Calvarial defect
Bone dust
ANTERIOR
Craniosynostosis
03 medical and health sciences
Craniosynostoses
Young Adult
Imaging
Three-Dimensional
Age groups
medicine
Humans
ta217
Retrospective Studies
REPAIR
Ossification
business.industry
Infant
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
Surgery
Bone Substitutes
SITE MORBIDITY
business
Tomography
X-Ray Computed
MATRIX
030217 neurology & neurosurgery
Zdroj: Journal of plastic, reconstructiveaesthetic surgery : JPRAS. 70(1)
ISSN: 1878-0539
2008-2010
Popis: Correction of calvarial defects after calvarial vault reconstruction (CVR) is challenging in craniosynostosis patients of advanced age and typically employs autologous bone. Demineralized bone matrix (DBM) is a potential alternative material for autologous bone, but its use has not been extended to correct calvarial defects. CVR patients operated at the Department of Plastic Surgery, Helsinki University Hospital, during 2008-2010 were retrospectively reviewed. Inclusion criteria of the study were CVR patients who received DBM plate, with or without bone dust, on calvarial defects and who had suitable uncovered defect on the contralateral side as control. This study included 17 craniosynostosis and one positional plagiocephaly patient, whose mean age was 6.9 years (range 0.9-19 years). The mean follow-up time was 5.6 years. The fusion degree of all defects was measured from 1 week to 1 year postoperatively using three-dimensional computed tomography (3D CT) images by the OsiriX (R) method. Medical records were reviewed for DBM-related complications. A total of 26 defects were covered with a DBM plate (mean area 11.1 cm(2)) and 26 control defects were identified (mean area 7.8 cm2). The mean fusion degree of the DBM defects was 74% and 54% for the controls (p 30 months) than in younger patients or when used with bone dust. (C) 2016 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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