Comparing Gas–Liquid Segmented and Tube-in-Tube Setups for the Aerobic Dimerization of Desmethoxycarpacine with an Automated Flow Platform
| Autor: | Elvina Barré, Lynda Ekou, Mireia Rodriguez-Zubiri, Ehu Camille Aka, François-Xavier Felpin, Daniel Cortés-Borda, Eric Wimmer, Tchirioua Ekou |
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| Přispěvatelé: | Laboratoire d'Informatique de Nantes Atlantique (LINA), Centre National de la Recherche Scientifique (CNRS)-Mines Nantes (Mines Nantes)-Université de Nantes (UN), Université Nangui Abrogoua, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
010405 organic chemistry business.industry Continuous reactor Organic Chemistry Flow (psychology) Flow chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences [CHIM]Chemical Sciences Mass transfer rate Tube (fluid conveyance) Molecular oxygen Physical and Theoretical Chemistry Process engineering business ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Organic Process Research and Development Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.745-751. ⟨10.1021/acs.oprd.9b00525⟩ |
| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/acs.oprd.9b00525⟩ |
| Popis: | The hazardous nature of molecular oxygen can be mitigated with the use of flow reactors of small size, which in turn accelerate the gas-to-liquid mass transfer rate. In this contribution, we describe a reconfigurable automated flow platform integrating on-line HPLC monitoring for the cobalt-catalyzed aerobic oxidative dimerization of desmethoxycarpacine to carpanone. The flow platform was configured for aerobic oxidation under either a gas–liquid segmented or tube-in-tube strategy. An extensive optimization study concluded that the tube-in-tube device was penalized by the use of expensive and fragile Teflon AF-2400 tubing while the gas–liquid segmented setup featured higher yields (62% vs 48%), shorter reaction times (5 min vs 20 min), and better robustness. |
| Databáze: | OpenAIRE |
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