Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye
| Autor: | Eilidh Martin, E. Ian Pearce, Katherine M. Oliver, Peter A. Simmons, Alan Tomlinson, Suzanne Hagan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Immunology Evaporation rate Biochemistry Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Immunology and Allergy Medicine Humans Sign/symptom Molecular Biology Hydroxypropyl guar business.industry Hematology Middle Aged Crossover study Tear osmolarity 030104 developmental biology Tears 030221 ophthalmology & optometry Cytokines Dry Eye Syndromes Female Inflammation Mediators Ophthalmic Solutions business Biomarkers |
| Zdroj: | Cytokine. 105 |
| ISSN: | 1096-0023 |
| Popis: | Purpose Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. Methods In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At each visit, symptoms, tear evaporation rate, stability and osmolarity were measured and tear samples were analyzed for 7 inflammatory markers, using multiplex immunoassays. The 3 treatments included carboxymethylcellulose-glycerine-castor oil (CGC), carboxymethylcellulose (CMC) and hydroxypropyl guar (HPG). The CGC and HPG drops are emulsified lipids; CGC also contains osmoprotectants. The CMC drop is a standard aqueous polymeric supplement. Results Significant improvements were seen in symptoms (OSDI) and tear stability (NITBUT) with all 3 treatments at 4 weeks. At 4 weeks post-CGC, 6 out of 7 biomarkers demonstrated a >25% reduction (in 40% of subjects). The same reduction (>25%) was seen in 10% of the subjects for CMC and in none of the subjects for HPG. No significantly different change to either evaporation rate or tear osmolarity was found following any of the three treatments. Conclusions In this study, the CGC treatment resulted in the greatest reduction in ocular biomarkers of inflammation, while all 3 treatments reduced symptoms and improved tear stability. These results indicate that subject-perceived symptomatic improvements are not necessarily associated with a reduction in objective measures of inflammation. |
| Databáze: | OpenAIRE |
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