Extracellular vesicles: novel communicators in lung diseases
| Autor: | Navneet K. Dhillon, Nicholas S. Britt, Stuti Agarwal, Matthias Clauss, Aradhana Mohan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Lung Diseases
ARDS Cell signaling Endothelium Cell Communication Review Exosomes Extracellular Vesicles Cell-Derived Microparticles medicine Humans Progenitor cell Lung cancer lcsh:RC705-779 Lung business.industry Mesenchymal stem cell lcsh:Diseases of the respiratory system respiratory system medicine.disease Microvesicles respiratory tract diseases medicine.anatomical_structure Cancer research business Biomarkers |
| Zdroj: | Respiratory Research, Vol 21, Iss 1, Pp 1-21 (2020) Respiratory Research |
| Popis: | The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies. In addition to the endothelium, EVs may arise from alveolar macrophages, fibroblasts and epithelial cells. Because EVs harbor cargo molecules, such as miRNA, mRNA, and proteins, these intercellular communicators provide important insight into the health and disease condition of donor cells and may serve as useful biomarkers of lung disease processes. This comprehensive review focuses on what is currently known about the role of EVs as markers and mediators of lung pathologies including COPD, pulmonary hypertension, asthma, lung cancer and ALI/ARDS. We also explore the role EVs can potentially serve as therapeutics for these lung diseases when released from healthy progenitor cells, such as mesenchymal stem cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |