Quantitative susceptibility-weighted imaging in amyotrophic lateral sclerosis with 3.0 T magnetic resonance imaging
| Autor: | Lin Ma, Mengyu Liu, Jinfeng Li, Zhiye Chen, Hua-Feng Xiao |
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| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Biochemistry 030218 nuclear medicine & medical imaging 03 medical and health sciences R5-920 0302 clinical medicine Nuclear magnetic resonance Humans magnetic resonance imaging Medicine Amyotrophic lateral sclerosis quantitative susceptibility mapping medicine.diagnostic_test business.industry Amyotrophic Lateral Sclerosis phase-shift values Biochemistry (medical) Motor Cortex Brain Quantitative susceptibility mapping Magnetic resonance imaging Cell Biology General Medicine medicine.disease susceptibility-weighted imaging nervous system Susceptibility weighted imaging motor neuron disease business 030217 neurology & neurosurgery Retrospective Clinical Research Report |
| Zdroj: | Journal of International Medical Research, Vol 49 (2021) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060521992222 |
| Popis: | Objective To evaluate alterations in phase-shift values in the gray matter of patients with amyotrophic lateral sclerosis (ALS) using susceptibility-weighted imaging (SWI). Methods Twenty patients with definite or probable ALS and 19 age- and sex-matched healthy controls were enrolled. SWI was performed using a 3.0 T magnetic resonance imaging scanner. Phase-shift values were measured in corrected phase images using regions of interest, which were placed on the bilateral precentral gyrus, frontal cortex, caudate nucleus, globus pallidus, and putamen. Results Phase-shift values of the precentral gyrus were significantly lower in ALS patients (−0.176 ± 0.050) than in the control group (−0.119 ± 0.016) on SWI. The average phase-shift values of the frontal cortex, caudate nucleus, globus pallidus, and putamen in ALS patients (−0.089 ± 0.023, −0.065 ± 0.016, −0.336 ± 0.191, and −0.227 ± 0.101, respectively) were not significantly different from those in the healthy controls (−0.885 ± 0.015, −0.079 ± 0.018, −0.329 ± 0.136, and −0.229 ± 0.083, respectively). Conclusions Compared with healthy controls, ALS patients had a lower phase-shift value in the precentral gyrus, which may be related to abnormal iron overload. Thus, SWI is a potential method for identifying ALS patients. |
| Databáze: | OpenAIRE |
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