Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism in Idiopathic Nephrotic Syndrome in Kuwaiti Arab Children
| Autor: | Braham S Srivastva, Amal Al-Eisa, Mohammad Z. Haider |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Urology Peptidyl-Dipeptidase A Nephropathy Immunopathology Internal medicine Renin–angiotensin system Genotype Humans Medicine Child Polymorphism Genetic biology business.industry Infant Angiotensin-converting enzyme Glomerulonephritis medicine.disease Endocrinology Kuwait Nephrology Child Preschool biology.protein Female business Nephrotic syndrome Kidney disease |
| Zdroj: | Scandinavian Journal of Urology and Nephrology. 35:239-242 |
| ISSN: | 1651-2065 0036-5599 |
| Popis: | Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism influence the circulating and cellular levels of ACE and has been shown to be a risk factor in a number of diseases including IgA nephropathy. We have investigated the association of ACE gene I/D polymorphism with the clinical presentation of idiopathic nephrotic syndrome (INS) in Kuwaiti children.The genotypes for ACE gene I/D polymorphism were determined in 102 subjects (54 INS cases and 48 healthy controls) using a PCR method.The distribution of DD, ID and II genotypes was 70%, 20% and 10% in INS cases compared with 52%, 46% and 2% in the controls. The mean age of onset of the disease was significantly lower in the INS cases with DD genotype (37 months) compared with cases with II genotype (65 months, p0.05). The clinical manifestation of the disease was considerably severe in cases with DD genotypes compared with cases having ID and II genotypes. The INS cases with DD genotype also showed a significantly higher incidence of steroid sensitivity and steroid dependence. Seventy-three per cent of the INS cases with minimal change lesion had a DD genotype. Also 70% of the cases which needed cytotoxic drugs had DD genotype.Our data suggest an association of the D-allele of the ACE gene I/D polymorphism with the clinical manifestation of INS in Kuwaiti Arab children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|