| Autor: |
Mario F. C. Santos, Karen de J. Nicácio, Albert Katchborian-Neto, Miller S. Ferreira, Daniel de Oliveira Miranda, João V. Andrade, Herinque de A. Pereira, Ester Gonçalves de Jesus, Thamires B, Silva Souza, Raquel P. Morais-Urano, Danielle Ferreira Dias, Daniela A. Chagas-Paula, Marisi G. Soares |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.21120306.v1 |
| Popis: |
The phytochemical investigation of the stem bark crude extract of Aniba firmula (Lauraceae) led to the isolation of undescribed bicyclic [3.2.1] octane neolignans, 1 and 2, characterized by unusual bicyclic patterns and two other known bicyclic neolignans 3 and 4. Anti-inflammatory bicyclic [3.2.1] octane neolignans metabolites were previously reported in the literature, and the A. firmula stands out in the Lauraceae family as a source of potentially bioactive compounds. Thus, herein the anti-inflammatory potential of four isolated compounds from A. firmula was accessed via an ex vivo anti-inflammatory model that included plasmatic quantification of the prostaglandin E2 (PGE2) inflammatory mediator. Compounds 2 and 3 exhibited significant anti-inflammatory activity by inhibiting the production of PGE2 in plasma samples, thus by interference with the cyclooxygenase (COX) inflammatory pathway. Therefore, these findings demonstrate that the bicyclic octane neolignan classes [3.2.1] can present anti-inflammatory potential. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
