Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review

Autor: Marko Kerac, James A. Berkley, Prasad S. Dalvi, Robert H. J. Bandsma, Marion G. Priebe, Wieger Voskuijl, Matilda E. Arvidsson Kvissberg
Přispěvatelé: General Paediatrics, APH - Global Health, AII - Infectious diseases
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Pediatrics
Malabsorption
Protein–energy malnutrition
Medicine (miscellaneous)
Disaccharidase deficiency
Lactose
Weight Gain
0302 clinical medicine
LACTOSE ABSORPTION
ACQUIRED DISACCHARIDE INTOLERANCE
030212 general & internal medicine
Child
KWASHIORKOR
EARLY RECOVERY
2. Zero hunger
Nutrition and Dietetics
Kwashiorkor
3. Good health
Diarrhea
DIETARY LACTOSE
medicine.symptom
F-75
malnutrition
SUGAR INTOLERANCE
medicine.medical_specialty
Carbohydrate malabsorption
Severe Acute Malnutrition
Context (language use)
Child Nutrition Disorders
03 medical and health sciences
DIGESTION
030225 pediatrics
Internal medicine
medicine
Dietary Carbohydrates
PROTEIN-ENERGY MALNUTRITION
MANAGEMENT
Humans
Nutrition in Clinical Care
Lactose intolerance
business.industry
Malnutrition
Infant
medicine.disease
DIARRHEA
Diet
Endocrinology
business
Zdroj: Nutrition reviews, 74(1):nuv058, 48-58. Wiley-Blackwell
Nutrition Reviews
ISSN: 0029-6643
Popis: Context: Severe acute malnutrition (SAM) accounts for approximately 1 million child deaths per year. High mortality is linked with comorbidities, such as diarrhea and pneumonia. Objective: The aim of this systematic review was to determine the extent to which carbohydrate malabsorption occurs in children with SAM. Data Sources: The PubMed and Embase databases were searched. Reference lists of selected articles were checked. Data Extraction: All observational and controlled intervention studies involving children with SAM in which direct or indirect measures of carbohydrate absorption were analyzed were eligible for inclusion. A total of 20 articles were selected for this review. Data Synthesis: Most studies reported carbohydrate malabsorption, particularly lactose malabsorption, and suggested an increase in diarrhea and reduced weight gain in children on a lactose-containing diet. As most studies reviewed were observational, there was no conclusive scientific evidence of a causal relationship between lactose malabsorption and a worse clinical outcome among malnourished children. Conclusion: The combined data indicate that carbohydrate malabsorption is prevalent in children with SAM. Additional well-designed intervention studies are needed to determine whether outcomes of SAM complicated by carbohydrate malabsorption could be improved by altering the carbohydrate/lactose content of therapeutic feeds and to elucidate the precise mechanisms involved.
Databáze: OpenAIRE
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