Regulation of adiponectin gene expression in adipose tissue by thyroid hormones
| Autor: | Saed Nazifi, Samira Seifi, Mohammad Reza Tabandeh, Sadegh Shirian, M. Saeb, Parisa Sarkoohi |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Transcription Genetic Physiology Levothyroxine Adipose tissue Biology Fatty Acids Nonesterified Intra-Abdominal Fat Real-Time Polymerase Chain Reaction Biochemistry Hyperthyroidism Rats Sprague-Dawley chemistry.chemical_compound Hypothyroidism In vivo Internal medicine Gene expression medicine Animals Regulation of gene expression Triglyceride Adiponectin nutritional and metabolic diseases General Medicine Lipids Rats Thyroxine Endocrinology Real-time polymerase chain reaction chemistry Gene Expression Regulation Triiodothyronine medicine.drug |
| Zdroj: | Journal of physiology and biochemistry. 68(2) |
| ISSN: | 1877-8755 |
| Popis: | Available experimental data suggest that adiponectin and thyroid hormones have biological interaction in vivo. However, the effects of thyroid hormones on adipose adiponectin gene expression in thyroid dysfunction are unclear. We induced hyper- (HYPER) and hypothyroidism (HYPO) by daily administration of a 12 mg/l of levothyroxine and 250 mg/l of methimazole in drinking water of rats, respectively, for 42 days. The white adipose tissues and serum sample were taken on days 15, 28, 42 and also 2 weeks after treatment cessation. Analysis of adiponectin gene expression was performed by real-time PCR and 2−ΔΔct method. The levels of adipose tissue adiponectin mRNA in the HYPO rats were decreased during the 6-week treatment when compared to control rats ( |
| Databáze: | OpenAIRE |
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