Effects of Early Maternal Docosahexaenoic Acid Intake on Neuropsychological Status and Visual Acuity at Five Years of Age of Breast-Fed Term Infants
| Autor: | Judith C Rozelle, Robert E. Anderson, Thomas C. Prager, Antolin M. Llorente, Yali L. Zou, Craig L. Jensen, William C. Heird, Sarika U. Peters, Robert G. Voigt, J. Kennard Fraley, Marie Turcich |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Visual acuity Docosahexaenoic Acids genetic structures Term Birth Visual Acuity Breastfeeding Neuropsychological Tests Placebo Child Development Pregnancy medicine Humans Psychomotor learning Kaufman Assessment Battery for Children business.industry Leiter International Performance Scale Prenatal Care medicine.disease Breast Feeding Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business Breast feeding Psychomotor Performance |
| Zdroj: | The Journal of Pediatrics. 157:900-905 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/j.jpeds.2010.06.006 |
| Popis: | We previously reported better psychomotor development at 30 months of age in infants whose mothers received a docosahexaenoic acid (DHA) (22:6n-3) supplement for the first 4 months of lactation. We now assess neuropsychological and visual function of the same children at 5 years of age.Breastfeeding women were assigned to receive identical capsules containing either a high-DHA algal oil (∼200 mg/d of DHA) or a vegetable oil (containing no DHA) from delivery until 4 months postpartum. Primary outcome variables at 5 years of age were measures of gross and fine motor function, perceptual/visual-motor function, attention, executive function, verbal skills, and visual function of the recipient children at 5 years of age.There were no differences in visual function as assessed by the Bailey-Lovie acuity chart, transient visual evoked potential or sweep visual evoked potential testing between children whose mothers received DHA versus placebo. Children whose mothers received DHA versus placebo performed significantly better on the Sustained Attention Subscale of the Leiter International Performance Scale (46.5 ± 8.9 vs 41.9 ± 9.3, P.008) but there were no statistically significant differences between groups on other neuropsychological domains.Five-year-old children whose mothers received modest DHA supplementation versus placebo for the first 4 months of breastfeeding performed better on a test of sustained attention. This, along with the previously reported better performance of the children of DHA-supplemented mothers on a test of psychomotor development at 30 months of age, suggests that DHA intake during early infancy confers long-term benefits on specific aspects of neurodevelopment. |
| Databáze: | OpenAIRE |
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