Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis
| Autor: | Xiaohua Huang, Zhongshi Huang, Zhongheng Wei, Yun Feng, Xuebin Li, Anding Xu, Chongdong Jian |
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| Rok vydání: | 2021 |
| Předmět: |
Science & Technology
General Immunology and Microbiology Article Subject Brain Computational Biology Epithelial Cells General Medicine Research & Experimental Medicine DEPRESSION Kidney General Biochemistry Genetics and Molecular Biology Biotechnology & Applied Microbiology Medicine Research & Experimental Medicine Homeostasis Humans Transcriptome Life Sciences & Biomedicine STROKE Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2022 (2022) |
| ISSN: | 2314-6141 |
| Popis: | Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression. ispartof: BIOMED RESEARCH INTERNATIONAL vol:2022 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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