Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms
| Autor: | Vahid Shaygannejad, Sayyed-Hamid Zarkesh-Esfahani, Marjan Gharagozloo, Abbasali Pourazar, Azam Jamshidian |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Multiple Sclerosis Adolescent Immunology Prodromal Symptoms chemical and pharmacologic phenomena Disease Severity of Illness Index T-Lymphocytes Regulatory Immunophenotyping Correlation Young Adult Multiple Sclerosis Relapsing-Remitting Immune system Recurrence Humans Immunology and Allergy Medicine Th17 differentiation Balance (ability) business.industry Multiple sclerosis Forkhead Transcription Factors hemic and immune systems Middle Aged medicine.disease Phenotype Peripheral blood Neurology Th17 Cells Female Neurology (clinical) business |
| Zdroj: | Journal of Neuroimmunology. 262:106-112 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2013.06.007 |
| Popis: | The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease. |
| Databáze: | OpenAIRE |
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