The Neurological Complexities and Prognosis of COVID-19
| Autor: | Nimrat Khehra, Mayur Parmar, Inderbir S. Padda, Urooj Jaferi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Encephalopathy Neurologic complications Pathophysiology Neurological signs and symptoms Mechanisms Medicine Meningitis Necrotizing encephalopathy Cerebrovascular disease Literature review Intracerebral hemorrhage PNS symptoms SARS-CoV-2 business.industry Systematic literature review COVID-19 Retrospective cohort study Neurologic manifestations Viral encephalitis medicine.disease Review article Coronavirus Acute Transverse Myelitis Headaches medicine.symptom business CNS symptoms |
| Zdroj: | Sn Comprehensive Clinical Medicine SN Comprehensive Clinical Medicine |
| ISSN: | 2523-8973 |
| DOI: | 10.1007/s42399-020-00527-2 |
| Popis: | Several neurological manifestations and complications linked to SARS-CoV-2 have been reported along with well-known respiratory pathology. The global active transmission of SARS-CoV-2 and its unexplained characteristics has led to a pandemic. Since its rapid emergence from Wuhan, China, in December 2019, several studies have reported the impacts of COVID-19 on the CNS and PNS and its implications. This comprehensive review article comprises case reports, case series, metaanalysis, cohort studies, retrospective studies, and narrative reviews focusing on COVID-19-associated CNS and PNS complexities. The authors searched for over 200 articles and used 52 publications related to the neurological complexities of COVID-19 affecting the CNS and PNS as part of the literature review process. The predominant CNS symptoms noted in COVID-19 patients were headaches and dizziness, and the most common PNS symptoms were alterations in smell and taste. Case reports on headache/dizziness, intracerebral hemorrhage, acute hemorrhagic necrotizing encephalopathy, meningitis/encephalitis, encephalopathy, cerebrovascular events, chemosensory dysfunction, Guillain-Barre syndrome, and acute transverse myelitis/acute necrotizing myelitis in PCR-confirmed SARS-CoV-2 subjects are also reported. New-onset neurological symptoms were also observed in children with PCR-confirmed SARS-CoV-2 that developed pediatric multisystem inflammatory syndrome (PIMS). This comprehensive review article will assist the clinicians and researchers to gain information about the neurological manifestations and complications associated with COVID-19 and develop planning to treat these symptoms in concerned patients of all ages. However, it is unclear whether SARS-CoV2-associated neurological effects are due to primary infections or secondary response to the possible mechanisms discussed in this review. |
| Databáze: | OpenAIRE |
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