Circulating Ghrelin Levels Are Suppressed by Meals and Octreotide Therapy in Children with Prader-Willi Syndrome
| Autor: | Katherine L. Pratt, Stephen H. LaFranchi, Jonathan Q. Purnell, Andrea M. Haqq, Ron G. Rosenfeld, David E. Cummings, Diane D. Stadler, David S. Weigle, R. Scott Frayo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Leptin
Male Agonist medicine.medical_specialty medicine.drug_class Peptide Hormones Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Octreotide Pilot Projects Hyperphagia Biochemistry Endocrinology Weight loss Internal medicine medicine Humans Insulin Resting energy expenditure Obesity Insulin-Like Growth Factor I Child Behavior business.industry Body Weight digestive oral and skin physiology Biochemistry (medical) nutritional and metabolic diseases Ghrelin Hormones Insulin-Like Growth Factor Binding Protein 3 Somatostatin Food Body Composition Female medicine.symptom business Prader-Willi Syndrome hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 88:3573-3576 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2003-030205 |
| Popis: | Prader-Willi syndrome (PWS) is characterized by severe obesity, hyperphagia, hypogonadism, and GH deficiency. Unlike individuals with common obesity, who have low fasting-plasma ghrelin concentrations, those with PWS have high fasting-ghrelin concentrations that might contribute to their hyperphagia. Treatment with octreotide, a somatostatin agonist, decreases ghrelin concentrations in healthy and acromegalic adults and induces weight loss in children with hypothalamic obesity. This pilot study was performed to determine whether octreotide administration (5 microg/kg.d) for 5-7 d lowers ghrelin concentrations and affects body composition, resting energy expenditure, and GH markers in children with PWS. Octreotide treatment decreased mean fasting plasma ghrelin concentration by 67% (P0.05). Meal-related ghrelin suppression (-35%; P0.001) was still present after intervention but was blunted (-11%; P = 0.19). Body weight, body composition, leptin, insulin, resting energy expenditure, and GH parameters did not change. However, one subject's parent noted fewer tantrums over denial of food during octreotide intervention. In conclusion, short-term octreotide treatment markedly decreased fasting ghrelin concentrations in children with PWS but did not fully ablate the normal meal-related suppression of ghrelin. Further investigation is warranted to determine whether long-term octreotide treatment causes sustained ghrelin suppression, changes eating behavior, and induces weight loss in this population. |
| Databáze: | OpenAIRE |
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