Some Metabolites Act as Second Messengers in Yeast Chronological Aging

Autor: Mélissa McAuley, Karamat Mohammad, Younes Medkour, Vladimir I. Titorenko, Pamela Dakik, Darya Mitrofanova
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Cell signaling
second messengers
mechanisms of longevity regulation
Saccharomyces cerevisiae
Review
yeast
Second Messenger Systems
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
cell signaling
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
2. Zero hunger
proteostasis
biology
chronological aging
Chemistry
Cell Cycle
Organic Chemistry
regulated cell death
General Medicine
Metabolism
biology.organism_classification
Trehalose
Yeast
Computer Science Applications
mitochondria
interorganellar communications
030104 developmental biology
Proteostasis
Biochemistry
lcsh:Biology (General)
lcsh:QD1-999
Second messenger system
Signal transduction
metabolism
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 3, p 860 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: The concentrations of some key metabolic intermediates play essential roles in regulating the longevity of the chronologically aging yeast Saccharomyces cerevisiae. These key metabolites are detected by certain ligand-specific protein sensors that respond to concentration changes of the key metabolites by altering the efficiencies of longevity-defining cellular processes. The concentrations of the key metabolites that affect yeast chronological aging are controlled spatially and temporally. Here, we analyze mechanisms through which the spatiotemporal dynamics of changes in the concentrations of the key metabolites influence yeast chronological lifespan. Our analysis indicates that a distinct set of metabolites can act as second messengers that define the pace of yeast chronological aging. Molecules that can operate both as intermediates of yeast metabolism and as second messengers of yeast chronological aging include reduced nicotinamide adenine dinucleotide phosphate (NADPH), glycerol, trehalose, hydrogen peroxide, amino acids, sphingolipids, spermidine, hydrogen sulfide, acetic acid, ethanol, free fatty acids, and diacylglycerol. We discuss several properties that these second messengers of yeast chronological aging have in common with second messengers of signal transduction. We outline how these second messengers of yeast chronological aging elicit changes in cell functionality and viability in response to changes in the nutrient, energy, stress, and proliferation status of the cell.
Databáze: OpenAIRE
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