Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma

Autor: Jennifer Landsberg, Dennis Niebel, Emma Grace Bawden, Holger Fröhlich, Judith Sirokay, Glen Kristiansen, Friedrich Bootz, Anne Fröhlich, Sophia Loick, Gonzalo Saavedra, Simon Fietz, Romina Zarbl, Jörn Dietrich, Gerrit H. Gielen, Dimo Dietrich, Eric Diekmann
Přispěvatelé: Publica
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Research paper
medicine.medical_treatment
MAPK
Mitogen-activated protein kinase
lcsh:Medicine
Epigenesis
Genetic
4-1BB
0302 clinical medicine
Gene expression
Leukocytes
Neoplasm Metastasis
Melanoma
FFPET
Formalin-fixed and paraffin-embedded tissue
lcsh:R5-920
DNA methylation
NAT
Normal adjacent tissue
MR
Mixed response
CD137
PBMCs
Peripheral blood mononucleated cells
PD-1
Programmed cell death 1
General Medicine
Methylation
Prognosis
TNFRSF9
CTLA4
Cytotoxic T-lymphocyte associated protein 4
NA
Not assessable
Gene Expression Regulation
Neoplastic
Predictive biomarker
CpG site
Immune cell infiltration
NF-kB
Nuclear factor 'kappa-light-chain-enhancer' of activated B-cells
030220 oncology & carcinogenesis
Cytokines
IDH1
Isocitrate dehydrogenase 1
95% CI
95% confidence interval
Immune checkpoint
Immunotherapy
LAG3
lymphocyte activating 3
lcsh:Medicine (General)
PD
Progressive disease
IRB
Institutional Review Board
MYC
MYC proto-oncogene
Prognostic biomarker
n.c.
Normalized counts
Tregs
Regulatory T cells
General Biochemistry
Genetics and Molecular Biology
TILs
Tumor infiltrating lymphocytes
TPM
Transcripts per million
Interferon-gamma
Tumor Necrosis Factor Receptor Superfamily
Member 9
03 medical and health sciences
Lymphocytes
Tumor-Infiltrating
CR
Complete response
PFS
Progression-free survival
Response prediction
Biomarkers
Tumor
medicine
Humans
RNA
Messenger
PD-L1
Programmed cell death 1 ligand 1
Epigenetics
Neoplasm Staging
TNFRS9
Tumor necrosis factor receptor super family 9
business.industry
qMSP
quantitative methylation-specific PCR
lcsh:R
NK cells
Natural killer cells
PR
Partial response
HIF1-α
Hypoxia-inducible factor 1-alpha
030104 developmental biology
Case-Control Studies
OS
Overall survival
BRAF
V-raf murine sarcoma viral oncogene homolog B1
Cancer research
TCGA
The Cancer Genome Atlas
IL-2
Interleukin 2
LHR
Likelihood Ratio
Neoplasm Grading
SKCM
Skin cutaneous melanoma
business
ARID2
AT-rich interactive domain-containing protein 2
IFN-γ
Interferon gamma
TALs
Tumor-associated lymphocytes
Zdroj: EBioMedicine, Vol 52, Iss, Pp-(2020)
EBioMedicine
ISSN: 2352-3964
Popis: EBioMedicine 52, 102647 (2020). doi:10.1016/j.ebiom.2020.102647
Published by Elsevier, Amsterdam [u.a.]
Databáze: OpenAIRE
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