Review of canine dilated cardiomyopathy in the wake of diet-associated concerns
Autor: | Bradley W Quest, Sydney R McCauley, Renee M Streeter, Eva M. Oxford, Stephanie D Clark |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
040301 veterinary sciences Disease 0403 veterinary science 03 medical and health sciences Canine dilated cardiomyopathy Genetics medicine Genetic predisposition cardiovascular diseases Intensive care medicine 030304 developmental biology 0303 health sciences business.industry Confounding carnitine Dilated cardiomyopathy deficiency 04 agricultural and veterinary sciences General Medicine musculoskeletal system medicine.disease dilated cardiomyopathy Malnutrition Increased risk dog cardiovascular system Etiology AcademicSubjects/SCI00960 Animal Science and Zoology Board Invited Review diet taurine business Food Science |
Zdroj: | Journal of Animal Science |
ISSN: | 1525-3163 0021-8812 |
Popis: | Dilated cardiomyopathy (DCM) has been in the literature and news because of the recent opinion-based journal articles and public releases by regulatory agencies. DCM is commonly associated with a genetic predisposition in certain dog breeds and can also occur secondary to other diseases and nutritional deficiencies. Recent communications in veterinary journals have discussed a potential relationship between grain-free and/or novel protein diets to DCM, citing a subjective increase in DCM in dog breeds that are not known to have a genetic predisposition for the disease. This literature review describes clinical presentations of DCM, common sequelae, treatment and preventative measures, histopathologic features, and a discussion of the varied etiological origins of the disease. In addition, current literature limitations are addressed, in order to ascertain multiple variables leading to the development of DCM. Future studies are needed to evaluate one variable at a time and to minimize confounding variables and speculation. Furthermore, to prevent sampling bias with the current FDA reports, the veterinary community should be asked to provide information for all cases of DCM in dogs. This should include cases during the same time period, regardless of the practitioner’s proposed etiology, due to no definitive association between diets with specific characteristics, such as, but not limited to, grain-free diets and those containing legumes, novel protein diets, and those produced by small manufacturers to DCM in dogs. In summary, in order to determine if certain ingredients, categories of diets, or manufacturing processes are related to an increased risk of DCM, further studies investigating these variables are necessary. |
Databáze: | OpenAIRE |
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