Levels of interleukins 12 (IL-12) and 13 (IL-13), hepatitis B and C serology, and blood cultures among acute myeloid leukemia (AML) patients in Egypt
| Autor: | Harfoush Ra, Morsi Mg, Nour el deen Raa, Hamed Na, Elgharabawy Mm |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
HBsAg
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Hepatitis C virus acute myeloid leukemia Toxicology medicine.disease_cause Serology lcsh:RA1190-1270 lcsh:Zoology medicine lcsh:QL1-991 lcsh:Toxicology. Poisons Hepatitis B virus Hepatitis business.industry Hepatitis C Hepatitis B medicine.disease Virology Infectious Diseases IL-12 IL-13 Immunology HCV Animal Science and Zoology Parasitology ELISA business Viral hepatitis |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 3, Pp 293-299 (2011) Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 17, Issue: 3, Pages: 293-299, Published: 2011 Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.3 2011 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1678-9199 |
| Popis: | There is an interest in the use of IL-12 as a possible anti-cancer drug to induce immune responses and anti-IL-13 formulations to treat the undesirable effects of IL-13. Thus, the present study aimed at analyzing IL-12 and IL-13 profiles, viral hepatitis serology and blood cultures in acute myeloid leukemia (AML) patients. Forty individuals (20 without septicemia - Group A, and 20 with septicemia - Group B) and 20 healthy controls were evaluated. Hepatitis B virus antigens (HBsAg) and hepatitis C virus antibodies (HCV Ab) were quantified using commercial ELISA kits. IL-12 and IL-13 levels were estimated in culture supernatant of mitogen-stimulated peripheral blood mononuclear cells by ELISA. Significantly low IL-12 values were observed among AML patients compared to controls whereas the opposite was observed regarding IL-13. IL-12 levels were found to be elevated in the follow-up cases. M4 and M5 subtypes of AML presented higher IL-12 levels than M1 and M2 subtypes. The isolated organisms from AML with septicemia were Staphylococcus aureus (35%), Esherichia coli (25%), coagulase-negative staphylococci (25%), and Candida (15%). Fungemia cases showed higher IL-12 values than bacteremia cases. In conclusion, IL-12 and IL-13 should be further tested in large-scale studies to provide future immunotherapy against AML. |
| Databáze: | OpenAIRE |
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