Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?
| Autor: | JanWillem Duitman, C. Arnold Spek, Maarten F. Bijlsma, Etienne J Slapak, Cansu Tekin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MMP2 pancreatic cancer Review Matrix metalloproteinase Biology MMP9 MMP7 General Biochemistry Genetics and Molecular Biology Metastasis Extracellular matrix 03 medical and health sciences 0302 clinical medicine matrix metalloproteases Pancreatic cancer medicine lcsh:QH301-705.5 MMP General Immunology and Microbiology MMP14 PDAC medicine.disease 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Cancer research General Agricultural and Biological Sciences |
| Zdroj: | Biology, Vol 9, Iss 80, p 80 (2020) Biology |
| ISSN: | 2079-7737 |
| DOI: | 10.3390/biology9040080 |
| Popis: | Pancreatic cancer is a dismal disorder that is histologically characterized by a dense fibrotic stroma around the tumor cells. As the extracellular matrix comprises the bulk of the stroma, matrix degrading proteases may play an important role in pancreatic cancer. It has been suggested that matrix metalloproteases are key drivers of both tumor growth and metastasis during pancreatic cancer progression. Based upon this notion, changes in matrix metalloprotease expression levels are often considered surrogate markers for pancreatic cancer progression and/or treatment response. Indeed, reduced matrix metalloprotease levels upon treatment (either pharmacological or due to genetic ablation) are considered as proof of the anti-tumorigenic potential of the mediator under study. In the current review, we aim to establish whether matrix metalloproteases indeed drive pancreatic cancer progression and whether decreased matrix metalloprotease levels in experimental settings are therefore indicative of treatment response. After a systematic review of the studies focusing on matrix metalloproteases in pancreatic cancer, we conclude that the available literature is not as convincing as expected and that, although individual matrix metalloproteases may contribute to pancreatic cancer growth and metastasis, this does not support the generalized notion that matrix metalloproteases drive pancreatic ductal adenocarcinoma progression. |
| Databáze: | OpenAIRE |
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