An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis
| Autor: | Jiafen Hu, Karam El-Bayoumy, Vonn Walter, Joshua E. Muscat, Kun Ming Chen, Douglas B. Stairs, John P. Richie, Raphael P. Viscidi, Yuan Wan Sun, Neil D. Christensen |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Disease Alphapapillomavirus Malignancy Mass Vaccination Article Mice 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Tobacco Smoking medicine Animals Humans Papillomavirus Vaccines Risk factor Survival rate Tobacco Use Cessation Mouth Squamous Cell Carcinoma of Head and Neck business.industry Incidence Microbiota Incidence (epidemiology) Papillomavirus Infections Cancer medicine.disease Head and neck squamous-cell carcinoma Vaccination Disease Models Animal Oropharyngeal Neoplasms stomatognathic diseases 030104 developmental biology 030220 oncology & carcinogenesis Mouth Neoplasms business |
| Zdroj: | Cancer Prev Res (Phila) |
| ISSN: | 1940-6215 1940-6207 |
| DOI: | 10.1158/1940-6207.capr-20-0096 |
| Popis: | Head and neck squamous cell carcinoma (HNSCC) was the 7th most common malignancy worldwide in 2018 and despite therapeutic advances, the overall survival rate for oral squamous cell carcinoma (OSCC; ∼50%) has remained unchanged for decades. The most common types are OSCC and oropharyngeal squamous cell carcinoma (OPSCC, survival rate ∼85%). Tobacco smoking is a major risk factor of HNSCC. In the developed world, the incidence of OSCC is declining as a result of tobacco cessation programs. However, OPSCC, which is also linked to human papillomavirus (HPV) infection, is on the rise and now ranks as the most common HPV-related cancer. The current state of knowledge indicates that HPV-associated disease differs substantially from other types of HNSCC and distinct biological differences between HPV-positive and HPV-negative HNSCC have been identified. Although risk factors have been extensively discussed in the literature, there are multiple clinically relevant questions that remain unanswered and even unexplored. Moreover, existing approaches (e.g., tobacco cessation, vaccination, and chemoprevention) to manage and control this disease remain a challenge. Thus, in this review, we discuss potential future basic research that can assist in a better understanding of disease pathogenesis which may lead to novel and more effective preventive strategies for OSCC and OPSCC. |
| Databáze: | OpenAIRE |
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