Multi-Unit Floating Alginate System: Effect of Additives on Ciprofloxacin Release

Autor:	Jayanta Kumar Pandit, A. Srinatha
Rok vydání:	2008
Předmět:	Materials science Alginates Surface Properties Starch Drug Compounding Pharmaceutical Science Methylcellulose Bead Excipients Chitosan chemistry.chemical_compound Drug Delivery Systems Hypromellose Derivatives Anti-Infective Agents Ciprofloxacin medicine Multi unit Particle Size chemistry.chemical_classification Chromatography Gastric fluid Polysaccharides Bacterial General Medicine Polymer Solubility chemistry Delayed-Action Preparations visual_art visual_art.visual_art_medium Extended release medicine.drug
Zdroj:	Drug Delivery. 15:471-476
ISSN:	1521-0464 1071-7544
Popis:	In an attempt to fabricate floating beads of ciprofloxacin, drugloaded alginate beads were prepared by simultaneous external and internal gelation. The effect of blending of alginate with gellan, hydroxypropyl methylcellulose, starch, and chitosan on the bead properties were evaluated. Beads were spherical with incorporation efficiency in the range of 52.81 +/- 2.64 to 78.95 +/- 1.92%. Beads exhibited buoyancy over a period of 7-24 hr based on the formulation variables. In vitro release of ciprofloxacin from the alginate beads in simulated gastric fluid (SGF) (0.1 N HCl, pH 1.2), was influenced significantly (p0.001) by the properties and concentration of additives. Among the polymers incorporated into alginate beads. Hydroxy propyl methylcellulose (HPMC) provided an extended release over 7 hr. The drug release predominately followed Higuchi's square root model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f26b07ed03e511611fc82ca03fd728c https://doi.org/10.1080/10717540802329282 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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