High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia
Autor: | Dulcineia M. Albuquerque, Marcondes José de Vasconcelos Costa Sobreira, Maria de Fátima Sonati, Antonio R. Lucena-Araujo, Maria Heloisa Souza Lima Blotta, Aderson S Araujo, Adekunle Emmanuel Alagbe, Igor de Farias Domingos, Fernando Ferreira Costa, Marcos André Cavalcanti Bezerra, Magnun N. N. Santos, Rômulo Tadeu Dias de Oliveira, Carolina Lanaro, Diego A Pereira-Martins |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Hematology biology business.industry Interleukin Inflammation FISIOPATOLOGIA General Medicine medicine.disease Gastroenterology Sickle cell anemia Acute chest syndrome Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine biology.protein Medicine Interleukin 8 medicine.symptom business Interleukin 6 030215 immunology |
Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
Popis: | Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the expression of several inflammatory molecules. Therefore, it is conceivable that variations in levels of proinflammatory cytokines may act as a signaling of differential clinical course in SCA. Here, we evaluated the clinical impact of proinflammatory cytokines interleukin 1-β (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8) in 79 patients with SCA, followed in a single reference center from northeastern Brazil. The main clinical/laboratory data were obtained from patient interview and medical records. The proinflammatory markers IL-1β, IL-6, and IL-8 were evaluated by using commercially available enzyme-linked immunosorbent assay kits. According to levels of the proinflammatory markers, we observed that patients who had a higher frequency of VOC per year (P = 0.0236), acute chest syndrome (P = 0.01), leg ulcers (P = 0.0001), osteonecrosis (P = 0.0006), stroke (P = 0.0486), and priapism (P = 0.0347) had higher IL-6 levels compared with patients without these clinical complications. Furthermore, increased levels of IL-8 were found in patients who presented leg ulcers (P = 0.0184). No significant difference was found for IL-1β levels (P > 0.05). In summary, the present study emphasizes the role of inflammation in SCA pathophysiology, reveals an association of IL-8 levels and leg ulcer occurrence, and indicates that IL-6 levels can be used as a useful predictor for poor outcomes in SCA. |
Databáze: | OpenAIRE |
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