Endogenous or exogenous oligodendrocytes for remyelination
| Autor: | Karen-Amanda Irvine, William F. Blakemore |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Population
Inflammation Endogeny Biology medicine Animals Humans Remyelination education education.field_of_study Stem Cells Oligodendrocyte Nerve Regeneration Oligodendroglia stomatognathic diseases medicine.anatomical_structure nervous system Neurology Neuroglia Neurology (clinical) Astrocytosis medicine.symptom Neuroscience Demyelinating Diseases Stem Cell Transplantation Astrocyte |
| Zdroj: | Journal of the Neurological Sciences. 265:43-46 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2007.08.004 |
| Popis: | The relative merits of endogenous and exogenous oligodendrocyte progenitor cells (OPCs) for remyelination are compared in terms of their ability to repopulate OPC-depleted tissue and generate remyelinating oligodendrocytes. Exogenous neonatal OPCs can repopulate OPC-depleted tissue 5-10 times faster than endogenous cells and as a result are capable of more extensive remyelination. Both endogenous and exogenous cells will only repopulate normal tissue if there is extensive depletion of the local OPC population and both show reduced ability to generate remyelinating cells in the absence of acute inflammation. When endogenous OPCs are depleted by X-irradiation during cuprizone intoxication, where there is a combination of astrocytosis and acute demyelination, endogenous but not exogenous embryo-derived OPCs fail to repopulate the OPC-depleted cortex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect