Hyperammonemic encephalopathy without hepatic dysfunction due to treatment with valproate: four cases and a mini review
| Autor: | Şahin Bodur, Yasemin Taş Torun, Abdullah Bolu, M. Ayhan Cöngöloğlu, Hesna Gül, Mustafa Dincer, Miray Çetinkaya, Halil Kara, Cemil Çelik, Abdullah Akgun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Neurology hyperammonemia Encephalopathy Neurosciences. Biological psychiatry. Neuropsychiatry Gastroenterology Mini review 03 medical and health sciences Lactulose 0302 clinical medicine Internal medicine Valproic acid medicine Pharmacology (medical) Bipolar disorder bipolar disorder Valproic Acid business.industry Hyperammonemia encephalopathy medicine.disease 030227 psychiatry side effects Psychiatry and Mental health lactulose lipids (amino acids peptides and proteins) business Hepatic dysfunction 030217 neurology & neurosurgery RC321-571 medicine.drug |
| Zdroj: | Psychiatry and Clinical Psychopharmacology, Vol 28, Iss 4, Pp 448-460 (2018) |
| ISSN: | 2475-0581 2475-0573 |
| DOI: | 10.1080/24750573.2018.1448133 |
| Popis: | Divalproex sodium/valproic acid (VPA) is an antiepileptic drug which is frequently prescribed in neurology and psychiatric clinics. Common side effects of VPA are side effects of the digestive system, weight gain, tremor, sedation, hematologic side effects and hair loss. Valproate-induced hyperammonemia is almost seen in 50% of patients treated with VPA, some of which may develop encephalopathy. Valproate-induced hyperammonemic encephalopathy (NE) is a well-known subject and there are numerous publications in the current literature. Although there is substantial evidence for this side effect in patients with neurological disorders, the data in the psychiatric area are limited. When we look at publications, it seems that VHE is seen more often because it starts earlier in psychiatric patients, but we think that it is often missed. Here, we presented five cases in which we followed up and treated with VHE diagnosis in our clinic within one year and other reports published previously in a table. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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