COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes
| Autor: | Mabel Berrueta, Agustín Ciapponi, Xu Xiong, Natalia Zamora, Daniel Comandé, Federico Rodriguez Cairoli, Victoria Santa María, Pierre Buekens, Fernando J. Argento, Agustina Mazzoni, Sabra Zaraa, Ariel Bardach |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA viruses
Viral Diseases Pediatrics Neonatal intensive care unit Coronaviruses Epidemiology Physiology Maternal Health Fevers Severity of Illness Index Medical Conditions 0302 clinical medicine Pregnancy Medicine and Health Sciences Coughing Medicine 030212 general & internal medicine Pathology and laboratory medicine 030219 obstetrics & reproductive medicine Multidisciplinary Infectious disease transmission Pregnancy Outcome Obstetrics and Gynecology Medical microbiology Research Assessment Infectious Diseases Systematic review Viruses Premature Birth Female purl.org/becyt/ford/3 [https] Pathogens SARS CoV 2 medicine.symptom Research Article medicine.medical_specialty 2019-20 coronavirus outbreak SARS coronavirus Systematic Reviews Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science Research and Analysis Methods Microbiology Asymptomatic purl.org/becyt/ford/3.3 [https] 03 medical and health sciences Signs and Symptoms Humans SARS-CoV-2 business.industry Organisms Viral pathogens Biology and Life Sciences COVID-19 Neonates Covid 19 Odds ratio medicine.disease Infectious Disease Transmission Vertical Confidence interval Microbial pathogens Medical risk factors Low birth weight Medical Risk Factors Asymptomatic Diseases Women's Health Observational study Clinical Medicine Physiological Processes business Humanities Developmental Biology |
| Zdroj: | PLoS ONE, Vol 16, Iss 6, p e0253974 (2021) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal and child health following Cochrane methods and PRISMA statement for reporting (PROSPERO-CRD42020208783). Methods We searched literature databases and COVID-19 research websites from January to October 2020. We selected relevant SRs reporting adequate search strategy, data synthesis, risk of bias assessment, and/or individual description of included studies describing COVID-19 and pregnancy outcomes. Pair of reviewers independently selected studies through COVIDENCE web-software, performed the data extraction, and assessed its quality through the AMSTAR-2 tool. Discrepancies were resolved by consensus. Each SR’s results were synthesized and for the most recent, relevant, comprehensive, and with the highest quality, by predefined criteria, we presented GRADE evidence tables. Results We included 66 SRs of observational studies out of 608 references retrieved and most (61/66) had "critically low" overall quality. We found a relatively low degree of primary study overlap across SRs. The most frequent COVID-19 clinical findings during pregnancy were fever (28–100%), mild respiratory symptoms (20–79%), raised C-reactive protein (28–96%), lymphopenia (34–80%), and pneumonia signs in diagnostic imaging (7–99%). The most frequent maternal outcomes were C-section (23–96%) and preterm delivery (14–64%). Most of their babies were asymptomatic (16–93%) or presented fever (0–50%), low birth weight (5–43%) or preterm delivery (2–69%). The odds ratio (OR) of receiving invasive ventilation for COVID-19 versus non-COVID-19 pregnant women was 1.88 (95% Confidence Interval [CI] 1.36–2.60) and the OR that their babies were admitted to neonatal intensive care unit was 3.13 (95%CI 2.05–4.78). The risk of congenital transmission or via breast milk was estimated to be low, but close contacts may carry risks. Conclusion This comprehensive overview supports that pregnant women with COVID-19 may be at increased risk of adverse pregnancy and birth outcomes and low risk of congenital transmission. Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Bardach, Ariel Esteban. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Argento, Fernando J.. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Rodriguez Cairoli, Federico. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Zamora, Natalia. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Santa María, Victoria. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Xiong, Xu. University of Tulane; Estados Unidos Fil: Zaraa, Sabra. University of Washington; Estados Unidos Fil: Mazzoni, Agustina. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Buekens, Pierre. University of Tulane; Estados Unidos |
| Databáze: | OpenAIRE |
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