Normal Evoked Response to Rapid Sequences of Tactile Pulses in Autism Spectrum Disorders
| Autor: | Keri-Lee A. Garel, Sheraz Khan, Tal Kenet, Matti Hämäläinen, Santosh Ganesan |
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| Přispěvatelé: | Martinos Imaging Center at MIT, McGovern Institute for Brain Research at MIT, Khan, Sheraz |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Asperger’s syndrome
Sensory processing medicine.medical_treatment autism spectrum disorder Sensory system Somatosensory system Auditory cortex somatosensory lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cortex (anatomy) mental disorders medicine 0501 psychology and cognitive sciences lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Original Research High functioning autism MEG 05 social sciences medicine.disease 3. Good health Developmental disorder Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology Somatosensory evoked potential Autism spectrum disorder Cortex Psychology Neuroscience 030217 neurology & neurosurgery 050104 developmental & child psychology Cognitive psychology |
| Zdroj: | Frontiers Frontiers in Human Neuroscience, Vol 10 (2016) Frontiers in Human Neuroscience |
| Popis: | Autism spectrum disorder (ASD) is a developmental disorder diagnosed behaviorally, with many documented neurophysiological abnormalities in cortical response properties. While abnormal sensory processing is not considered core to the disorder, most ASD individuals report sensory processing abnormalities. Yet, the neurophysiological correlates of these abnormalities have not been fully mapped. In the auditory domain, studies have shown that cortical responses in the early auditory cortex in ASD are abnormal in multiple ways. In particular, it has been shown that individuals with ASD have abnormal cortical auditory evoked responses to rapid, but not slow, sequences of tones. In parallel, there is substantial evidence of somatosensory processing abnormalities in ASD, including in the temporal domain. Here, we tested the somatosensory domain in ASD for abnormalities in rapid processing of tactile pulses, to determine whether abnormalities there parallel those observed in the auditory domain. Specifically, we tested the somatosensory cortex response to a sequence of two tactile pulses with different (short and long) temporal separation. We analyzed the responses in cortical space, in primary somatosensory cortex. As expected, we found no group difference in the evoked response to pulses with long (700 ms) temporal separation. Contrary to findings in the auditory domain, we also found no group differences in the evoked responses to the sequence with a short (200 ms) temporal separation. These results suggest that rapid temporal processing deficits in ASD are not generalized across multiple sensory domains, and are unlikely to underlie the behavioral somatosensory abnormalities observed in ASD. Nancy Lurie Marks Family Foundation |
| Databáze: | OpenAIRE |
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