Risk Factors for Development of Rectal Neuroendocrine Tumors Longer Than 9 mm: Retrospective Cohort
| Autor: | Francisco Susumu Correa Koyama, Juliana Silveira Lima de Castro, Celso Augusto Milani Cardoso Filho, Wilson Toshihiko Nakagawa, Oswaldo Wiliam Marques, Paula Mendonça, Eloy Taglieri, Evandra Cristina Vieira da Rocha, Vanessa Assis do Vale |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer business.industry Rectal Neoplasms Medical record Cancer Retrospective cohort study Neuroendocrine tumors medicine.disease Neuroendocrine Tumors medicine.anatomical_structure Risk Factors Internal medicine Epidemiology medicine Humans Original Article business Lymph node Pathological Retrospective Studies |
| Zdroj: | Turk J Gastroenterol |
| ISSN: | 2148-5607 |
| Popis: | Background Rectal neuroendocrine tumors (R-NET) represent the most frequent of gastroenteropancreatic neuroendocrine neoplasms (NEN-GEP) according to the United States Surveillance, Epidemiology, and End Results database. With an annual percentage of occurrence increasing to 8.2% of all rectal neoplasms, R-NET affect less than 2% and are reported in only 0.05% to 0.07% of patients undergoing colorectal cancer (CRC) screening. The primary objective of this study was to assess the risk factors associated with R-NET greater than 10 mm. As a secondary objective, it was also aimed to evaluate the response to endoscopic treatment. Methods This was a retrospective study, using data collected through the analysis of medical records of colonoscopies performed from January 2008 to December 2014. Records of polypectomies were identified, and the results were searched for pathological findings of R-NET. We also gathered epidemiological data and outcomes as risk factors for lesions greater than or equal to 10 mm, with local and distant recurrence. Results During the study period, 18 218 colonoscopies were performed and 10 865 polypoid lesions were detected and removed, 20 with R-NET anatomopathology. The detection rate was 0.1%. The risk factors associated with major lesions were Japanese ethnicity, the lack of previous cancer diagnosis, and a Ki67 index > 2%. The mean follow-up was 56.6 months, and there was no local lymph node recurrence or distant relapse. Conclusion This study concludes that endoscopic resection is a good and effective method for treatment of Grade 1 rectal NET smaller than 11 mm, with high cure rates and low rates of local or distant relapse. |
| Databáze: | OpenAIRE |
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