Evaluation of blood parameters by linear discriminant models for the detection of testosterone administration
| Autor: | Vinod Nair, Andre K. Crouch, Daniel Eichner, Geoffrey D. Miller, Jacob D Husk, Ken Sharpe, Peter Van Eenoo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Reticulocytes medicine.drug_class Urinary system Pharmaceutical Science Endogeny Administration Cutaneous Injections Intramuscular 01 natural sciences Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Environmental Chemistry Testosterone 030216 legal & forensic medicine Spectroscopy Transdermal Doping in Sports Cross-Over Studies Dose-Response Relationship Drug business.industry 010401 analytical chemistry Discriminant Analysis Washout Dihydrotestosterone Middle Aged Linear discriminant analysis 0104 chemical sciences Substance Abuse Detection Endocrinology Androgens Linear Models Gonadotropin business Gels medicine.drug |
| Zdroj: | Drug Testing and Analysis. 13:1270-1281 |
| ISSN: | 1942-7611 1942-7603 |
| DOI: | 10.1002/dta.3017 |
| Popis: | The steroidal module of the Athlete Biological Passport (ABP) has been used since 2014 for the longitudinal monitoring of urinary testosterone and its metabolites to identify samples suspicious for the use of synthetic forms of Endogenous Anabolic Androgenic Steroids (EAAS). Multiple recent studies have suggested that monitoring of blood parameters may provide enhanced detectability of exogenous testosterone administration. Transdermal and intramuscular testosterone administration studies were carried out in 15 subjects, and the effect on blood steroidal levels, hematological parameters, and gonadotropins was evaluated. Serum testosterone and dihydrotestosterone levels increased while gonadotropin levels were suppressed after administration. A modest increase in reticulocytes was also observed. The blood parameters that were responsive to the administrations were combined into several linear discriminant models targeting both administration (on) and washout (off) phases. The models were effective in detecting the large dose intramuscular administration but were less successful in the detection of the lower dose transdermal application. The blood profiling models may provide complementary value but do not appear to be substantially more advantageous than longitudinal urinary profiling. |
| Databáze: | OpenAIRE |
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