Reproductive senescence and energetic metabolism of human luteinized granulosa cells: is it all about ATP? A prospective cohort and critical view
| Autor: | Juan A. Garcia-Velasco, Alberto Pacheco, Gustavo N. Cecchino |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Senescence Aging Endocrinology Diabetes and Metabolism Pilot Projects 030209 endocrinology & metabolism Fertilization in Vitro Mitochondrion Biology Cohort Studies Young Adult 03 medical and health sciences Reproductive senescence Adenosine Triphosphate 0302 clinical medicine Endocrinology Humans Prospective cohort study Cellular Senescence Granulosa Cells 030219 obstetrics & reproductive medicine Oocyte Donation Obstetrics and Gynecology Metabolism Cell biology Luteinization Case-Control Studies Female Reproductive capacity Energy Metabolism Infertility Female Function (biology) Maternal Age |
| Zdroj: | Gynecological Endocrinology. 37:523-527 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | Mitochondria are known to play a key role in the regulation of reproductive capacity. Senescence is known to impair mitochondrial function and, ultimately, cellular energetic metabolism. Therefore, as women age, a deficient energy supply is likely to affect oocyte quality. The analysis of granulosa cells is considered a valuable noninvasive strategy to assess factors implicated in oocyte competence. Thus, we conducted an observational prospective cohort to evaluate the impact of aging on energy production by luteinized granulosa cells (LGCs). The control group comprised 13 young oocyte donors, whereas the comparison group included 13 infertile women over 38 years of age undergoing |
| Databáze: | OpenAIRE |
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