HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma
| Autor: | Jordina Rovira, Antonio Martinez, Marc Xipell, Elias Campo, Luis Colomo, Daniel Martinez, Ester Monclús, Blanca Gonzalez-Farre, Mónica López-Guerra, Felipe García, Armando López-Guillermo |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pathology Lymphoma Lymphoproliferative disorders Lymphoid hyperplasia Pathology and Forensic Medicine Surgical pathology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Aged Aged 80 and over Clinical pathology business.industry virus diseases Anatomical pathology Herpesviridae Infections Middle Aged medicine.disease Lymphoproliferative Disorders 030104 developmental biology Cytopathology 030220 oncology & carcinogenesis Herpesvirus 8 Human Immunology Female medicine.symptom Hematopathology business |
| Zdroj: | Modern Pathology. 30:745-760 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.2016.233 |
| Popis: | Human herpesvirus 8 (HHV8)-associated lymphoid proliferations are uncommon and poorly characterized disorders mainly affecting immunosuppressed patients, especially with HIV infection. They encompass different diseases with overlapping features that complicate their classification. In addition, the role of HHV8 in reactive lymphoid hyperplasia is not well known. To analyze the clinicopathological spectrum of these lesions, we have reviewed 66 biopsies of 61 patients with HHV8 infection. All cases were also investigated for Epstein-Barr virus (EBV) and HIV infection. We identified 13 (20%) cases of HHV8-related reactive lymphoid hyperplasia, 2 (3%) HHV8 plasmablastic proliferations of the splenic red pulp, 28 (42%) multicentric Castleman disease, 6 (9%) germinotropic lymphoproliferative disorders, and 17 (26%) HHV8-related lymphomas. As expected, the pathologic subtype was predictive of overall survival (P |
| Databáze: | OpenAIRE |
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