The in-vitro influence of ceftazidime on host defence mechanisms
| Autor: | Håkan Gnarpe, Charlotte Blomqvist, Annika Lundbåck, Judy Belsheim, Ann-Christine Svensson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Neutrophils medicine.drug_class Cephalosporin Antibiotics Ceftazidime Microbial Sensitivity Tests Granulocyte Lymphocyte Activation medicine.disease_cause Microbiology Phagocytosis Cell Adhesion Escherichia coli medicine Humans Pharmacology (medical) Lymphocytes Cells Cultured Pharmacology biology Pseudomonas aeruginosa Chemotaxis biology.organism_classification Immunity Innate Cephalosporins Chemotaxis Leukocyte Infectious Diseases medicine.anatomical_structure Luminescent Measurements Mitogens Bacteria Granulocytes medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 13:369-375 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/13.4.369 |
| Popis: | The effects of ceftazidime, a new third generation cephalosporin, on host defence mechanisms, was investigated in vitro. No significant alteration of polymorphonuclear leukocyte chemotactic, phagocytic, or chemiluminescent responses were found. Granulocyte adherence to nylon fibre columns was increased by 10 mg/l or more of ceftazidime. Lymphocyte DNA synthesis was slightly decreased by high concentrations of ceftazidime, though not by therapeutic concentrations. Ceftazidime was found to stimulate the release of increased amounts of chemotaxis and phagocytosis-stimulating factors from Escherichia coli and Pseudomonas aeruginosa when bacteria were exposed to subminimal inhibitory concentrations of the antibiotic during active growth phases. |
| Databáze: | OpenAIRE |
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