Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers

Autor:	Stephen S. Hecht, Yan Zhang, Andrea R. Yoder, Adam R. Benoit, Steven G. Carmella, Kristin E. Anderson, Timothy R. Church, Diane Kampa, Chap T. Le
Rok vydání:	2010
Předmět:	Adult Nicotine Nitrosamines Pyridines Intraclass correlation Health Toxicology and Mutagenesis Urinary system Clinical Biochemistry Physiology Urine Plasma biomarkers Biochemistry Article Time Toxicology chemistry.chemical_compound medicine Humans Cotinine Aged Smoking Tobacco smoke exposure Middle Aged Phenanthrenes chemistry Phenanthrene tetraol Biomarkers medicine.drug
Zdroj:	Biomarkers. 15:345-352
ISSN:	1366-5804 1354-750X
DOI:	10.3109/13547501003753881
Popis:	Intraindividual variability of measurements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), nicotine, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT) over time is uncertain. From 70 habitual smokers' plasma and urine sampled bimonthly for a year we analysed plasma for NNAL, cotinine and PheT, and urine for NNAL, cotinine and nicotine. We estimated the intraclass correlation coefficients (rho(I)) for each measurement. Plasma and creatinine-corrected urinary NNAL were stable (rho(I) > or =70%); plasma PheT and plasma and urinary total cotinine were fairly stable (rho(I) > or =50%), but urinary nicotine rho(I) approximately 40% was not. Except for nicotine, single measurements from plasma or urine adequately represent individual mean exposure over time.
Databáze:	OpenAIRE
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