Incidence of congenital toxoplasmosis estimated by neonatal screening: relevance of diagnostic confirmation in asymptomatic newborn infants
| Autor: | Marisa Márcia Mussi-Pinhata, C. B. S. de Souza, Cristina Gardonyi Carvalheiro, Léa Maria Zanini Maciel, Aparecida Yulie Yamamoto |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Epidemiology Igm antibody Antibodies Protozoan Physical examination Disease Asymptomatic Toxoplasmosis Congenital Neonatal Screening Predictive Value of Tests Animals Humans Medicine biology medicine.diagnostic_test business.industry Incidence Incidence (epidemiology) Infant Newborn Congenital toxoplasmosis Infectious Diseases Immunoglobulin M biology.protein Female Antibody medicine.symptom business Toxoplasma Brazil Research Article |
| Zdroj: | Epidemiology and Infection. 133:485-491 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s095026880400353x |
| Popis: | Congenital toxoplasmosis is rarely identified by routine clinical examination. The aim of this study was to estimate the incidence of the disease in the region of Ribeirão Preto, south-eastern Brazil. A definitive diagnosis was made on the basis of the persistence of anti-Toxoplasma IgG antibodies beyond 1 year of age. Blood samples obtained from 15162 neonates and adsorbed onto filter paper were tested for anti-Toxoplasma IgM antibodies. Fifteen samples gave positive results. A definitive diagnosis was confirmed in five of the 13 infants (38·5%) who completed follow-up. These five infants presented with serum IgM and/or IgA antibodies, and clinical abnormalities. Disease incidence was estimated to be 3·3/10000 (95% CI 1·0–7·7), indicating the need for preventive measures. Neonatal screening is feasible, but screening tests with a better performance are required; positive screening results must be carefully confirmed. |
| Databáze: | OpenAIRE |
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