Lipid-based nutrient supplementation in the first 1000 d improves child growth in Bangladesh: a cluster-randomized effectiveness trial
| Autor: | Barkat Ullah, Showkat Ali Khan, Stephen A. Vosti, Malay K Mridha, Charles D Arnold, Susana L Matias, Zakia Siddiqui, Kathryn G. Dewey, Joseph Cummins, Zeina Maalouf-Manasseh |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Pediatrics medicine.medical_specialty Adolescent Offspring Iron Medicine (miscellaneous) Standard score 03 medical and health sciences Young Adult Folic Acid Pregnancy medicine Prevalence Humans Micronutrients Young adult Growth Disorders Food Formulated Bangladesh 030109 nutrition & dietetics Nutrition and Dietetics business.industry Infant Newborn Infant Maternal Nutritional Physiological Phenomena medicine.disease Micronutrient Dietary Fats Lipids Body Height Diet Malnutrition Child Preschool Dietary Supplements Gestation Female business Child Nutritional Physiological Phenomena Postpartum period |
| Zdroj: | The American journal of clinical nutrition. 105(4) |
| ISSN: | 1938-3207 0171-5038 |
| Popis: | Background: Stunting in linear growth occurs mainly during the first 1000 d, from conception through 24 mo of age. Despite the recognition of this critical period, there have been few evaluations of the growth impact of interventions that cover most of this window.Objective: We evaluated home fortification approaches for preventing maternal and child undernutrition within a community-based health program. We hypothesized that small-quantity lipid-based nutrient supplements (LNSs) provided to women during pregnancy and the first 6 mo postpartum, LNSs provided to their offspring from 6 to 24 mo of age, or both would result in greater child length-for-age z score (LAZ) at 24 mo than iron and folic acid (IFA) provided to women during pregnancy and postpartum plus micronutrient powder (MNP) or no supplementation for their offspring from 6 to 24 mo.Design: We conducted a cluster-randomized effectiveness trial with 4 arms: 1) women and children both received LNSs (LNS-LNS group), 2) women received IFA and children received LNSs (IFA-LNS group), 3) women received IFA and children received MNP (IFA-MNP group), and 4) women received IFA and children received no supplements (IFA-Control group). We enrolled 4011 women at ≤20 wk of gestation within 64 clusters, each comprising the supervision area of a community health worker. Analyses were primarily performed by using ANCOVA F tests and Tukey-Kramer-corrected pairwise comparisons.Results: At 24 mo, the LNS-LNS group had significantly higher LAZ (+0.13 compared with the IFA-MNP group) and head circumference (+0.15 z score compared with the IFA-Control group); these outcomes did not differ between the other groups. Stunting prevalence (LAZ |
| Databáze: | OpenAIRE |
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