Neural Remodeling of the Left Atrium in Rats by Rosuvastatin Following Acute Myocardial Infarction

Autor: Zhi-Yuan Li, Meng-Zan Wang, Shao-Hua Zheng, Jiang-Rong Wang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
atrial remodeling
medicine.medical_specialty
Statin
QH301-705.5
medicine.drug_class
030204 cardiovascular system & hematology
arrhythmia
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Western blot
Internal medicine
medicine
Rosuvastatin
cardiovascular diseases
Myocardial infarction
Biology (General)
Gap-43 protein
General Immunology and Microbiology
medicine.diagnostic_test
biology
neural remodeling
General Neuroscience
nutritional and metabolic diseases
medicine.disease
medicine.anatomical_structure
Nerve growth factor
myocardial infarction
030220 oncology & carcinogenesis
Stellate ganglion
cardiovascular system
Cardiology
biology.protein
Immunohistochemistry
General Agricultural and Biological Sciences
rosuvastatin
medicine.drug
Research Article
Zdroj: Open Life Sciences
Open Life Sciences, Vol 14, Iss 1, Pp 603-610 (2019)
ISSN: 2391-5412
Popis: ObjectiveThis study aims to investigate the effect of rosuvastatin on sympathetic neural remodeling of the left atrium (LA) in rats after myocardial infarction (MI).MethodsRats were randomly divided into a three groups: sham group, statin group, and MI group. The mRNA expression levels of the growth-associated protein-43 (GAP43) and nerve growth factor (NGF) were measured by RT-PCR. Immunohistochemistry was used to detect the distribution and density of GAP43- and NGF-positive nerves. The expression levels of these proteins were quantified by Western blot.ResultsCompared with the sham group, the average optical density (AOD) values of GAP43 and nerve growth factor (NGF)-positive substances in the LA in the statin and MI groups were significantly higher (PPPPConclusionRosuvastatin could effectively improve the sympathetic neural remodeling of LA in MI rats.
Databáze: OpenAIRE
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