Proton MRS and quantitative MRI assessment of the short term neurological response to antiretroviral therapy in AIDS
| Autor: | Iain D. Wilkinson, Sarah Lunn, Margaret A Hall-Craggs, Michael J. G. Harrison, Martyn N.J. Paley, Stanton Newman, K.A. Miszkiel, Ian Williams, B.E. Kendall, R.J.S. Chinn, Robert F. Miller |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology AIDS Dementia Complex Neurological disorder Grey matter Creatine Antiviral Agents Gastroenterology White matter chemistry.chemical_compound Zidovudine Cerebrospinal fluid Atrophy Parietal Lobe Internal medicine medicine Humans medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure chemistry Papers Surgery Occipital Lobe Neurology (clinical) business medicine.drug |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 63:477-482 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.63.4.477 |
| Popis: | Objective—To investigate MRI and proton spectroscopy changes in five patients with HIV associated dementia complex (HADC) treated with antiretroviral therapy. Methods—Three markers were evaluated: (1) CSF/intracranial volume ratio; (2) T2 weighted signal ratio between parietooccipital white and subcortical grey matter; and (3) metabolite ratios from long echo time (TE=135 ms) single voxel proton spectra of parieto-occipital white matter. Results—Spectroscopic changes indicated initial increases in N-acetyl/(N-acetyl + choline + creatine) ratio (NA/(NA+ Cho+Cr)) and progression of atrophy after initiation of antiretroviral therapy in four of five patients. When the neurological status of the patients subsequently deteriorated (two offive patients), the NA/(NA+Cho+Cr) ratio also declined. Conclusions—spectroscopic changes mirror reversible neuronal dysfunction. These objective, non-invasive techniques may be used for monitoring the neurological eVects of antiretroviral drug therapy in patients with HADC. (J Neurol Neurosurg Psychiatry 1997;63:477‐482) |
| Databáze: | OpenAIRE |
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