Numerical modelling of blood rheology and platelet activation through a stenosed left coronary artery bifurcation

Autor: Emma K. Neale, Diana C. de Oliveira, Daniel M. Espino, David G. Owen, Duncan E.T. Shepherd
Rok vydání: 2021
Předmět:
Swine
Physiology
Hemodynamics
Hematocrit
Physical Chemistry
Animal Cells
Materials Physics
Medicine and Health Sciences
Platelet
Stenosis
Multidisciplinary
medicine.diagnostic_test
Chemistry
Viscosity
Physics
Models
Cardiovascular
Arteries
Hematology
Thrombosis
Coronary Vessels
Body Fluids
medicine.anatomical_structure
Blood
Physical Sciences
Cardiology
Medicine
Anatomy
Cellular Types
Rheology
Artery
Research Article
Platelets
medicine.medical_specialty
Science
Materials Science
Left coronary artery
Signs and Symptoms
Internal medicine
medicine.artery
medicine
Animals
Platelet activation
Thrombus
Blood Coagulation
Blood Cells
Coronary Stenosis
Biology and Life Sciences
Cell Biology
medicine.disease
Platelet Activation
Blood Counts
Chemical Properties
Cardiovascular Anatomy
Blood Vessels
Stress
Mechanical
Clinical Medicine
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259196 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
ISSN: 1932-6203
Popis: Coronary bifurcations are prone to atherosclerotic plaque growth, experiencing regions of reduced wall shear stress (WSS) and increased platelet adhesion. This study compares effects across different rheological approaches on hemodynamics, combined with a shear stress exposure history model of platelets within a stenosed porcine bifurcation. Simulations used both single/multiphase blood models to determine which approach best predicts phenomena associated with atherosclerosis and atherothrombosis. A novel Lagrangian platelet tracking model was used to evaluate residence time and shear history of platelets indicating likely regions of thrombus formation. Results show a decrease in area of regions with pathologically low time-averaged WSS with the use of multiphase models, particularly in a stenotic bifurcation. Significant non-Newtonian effects were observed due to low-shear and varying hematocrit levels found on the outer walls of the bifurcation and distal to the stenosis. Platelet residence time increased 11% in the stenosed artery, with exposure times to low-shear sufficient for red blood cell aggregation (>1.5 s). increasing the risk of thrombosis. This shows stenotic artery hemodynamics are inherently non-Newtonian and multiphase, with variations in hematocrit (0.163–0.617) and elevated vorticity distal to stenosis (+15%) impairing the function of the endothelium via reduced time-averaged WSS regions, rheological properties and platelet activation/adhesion.
Databáze: OpenAIRE
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