Pharmaceuticals in Wastewater Treatment Plants: A Systematic Review on the Substances of Greatest Concern Responsible for the Development of Antimicrobial Resistance
| Autor: | Joanne Roberts, Ania Escudero, Deborah Reid, Janice Spencer, Karin Helwig, Colin Hunter, Gabriele Frascaroli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
010504 meteorology & atmospheric sciences medicine.drug_class QH301-705.5 QC1-999 Antibiotics 010501 environmental sciences occurrence 01 natural sciences Antibiotic resistance medicine General Materials Science antimicrobial resistance Biology (General) Instrumentation Effluent wastewater QD1-999 0105 earth and related environmental sciences Fluid Flow and Transfer Processes business.industry Process Chemistry and Technology Sulfamethoxazole removal Physics pharmaceutical residues General Engineering wastewater treatment plants Antimicrobial Engineering (General). Civil engineering (General) Trimethoprim atmospheric_science Computer Science Applications Biotechnology Chemistry Wastewater Sewage treatment TA1-2040 business medicine.drug |
| Zdroj: | Applied Sciences, Vol 11, Iss 6670, p 6670 (2021) |
| ISSN: | 2076-3417 |
| Popis: | In recent years, there is a growing concern about the alarming spread of antimicrobial resistance (AMR) in different environments. Increasingly, many species of bacteria, fungi and viruses are becoming immune to the most commonly used pharmaceuticals. One of the causes of the development of the resistance is the persistence of these drugs, excreted by humans, in municipal and hospital wastewater (WW). Consequently, wastewater treatment plants (WWTPs) are a primary source of antimicrobial resistance genes as novel pollutants. This systematic review sought to examine the relevant literature on pharmaceutical residues (PRs) responsible for AMR in municipal and hospital WW in order to propose a classification of the PRs of greatest concern and provide an updated source for AMR management in WWTPs. Among 546 studies collected from four databases, 18 were included in the present review. The internal and external validity of each study was assessed, and the risk of bias was evaluated on a 20-parameter basis. Results were combined in a narrative synthesis discussing influent and effluent PR concentrations at 88 WWTPs, seasonal variations, differences between hospital and municipal WW, environmental risk assessment values of antimicrobial substances and treatment facilities removal efficiencies. Among the 45 PRs responsible for AMR evaluated in this study, the antibiotics ciprofloxacin, clarithromycin, erythromycin, metronidazole, ofloxacin, sulfamethoxazole and trimethoprim constitute a considerable risk in terms of ubiquitous distribution, worrying concentrations, risk quotient values and resistance to removal treatments. Gaps in knowledge, data and information reported in this review will provide a valuable source for managing AMR in WWTPs. |
| Databáze: | OpenAIRE |
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